Phenotypes Associated with This Genotype

Genotype
MGI:5305584

• Allelic Composition: Foxo1^tm1.1Dac/Foxo1^tm1.1Dac
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:179687 )

• mice die between E11.5 and P12

cardiovascular system

abnormal blood vessel morphology ( J:179687 )

• reduced head vasculature and underdeveloped or missing aortic arch arteries

abnormal dorsal aorta morphology ( J:179687 )

• minimally developed in the head

• large and distended in the posterior

abnormal vitelline vasculature morphology ( J:179687 )

• development of the yolk vascular plexus is compromised

abnormal heart morphology ( J:179687 )

• distended at E9.5

abnormal myocardial trabeculae morphology ( J:179687 )

• disorganized trabeculi within the ventricle

abnormal heart development ( J:179687 )

enlarged pericardium ( J:179687 )

• at E10.5

absent heartbeat ( J:179687 )

• in all but one mouse at E10.5

• in all mice at E11.5

embryo

abnormal vitelline vasculature morphology ( J:179687 )

• development of the yolk vascular plexus is compromised

small first pharyngeal arch ( J:179687 )

• hypoplastic at E9.5

absent second pharyngeal arch ( J:179687 )

• absent or hypoplastic at E9.5

small second pharyngeal arch ( J:179687 )

• absent or hypoplastic at E9.5

abnormal embryo development ( J:179687 )

• at E11.5, all embryos are abnormal

embryonic growth retardation ( J:179687 )

• at E10.5

abnormal somite development ( J:179687 )

• small and irregular

abnormal somite shape ( J:179687 )

• irregular

decreased somite size ( J:179687 )

• small somites

growth/size/body

embryonic growth retardation ( J:179687 )

• at E10.5

craniofacial

small first pharyngeal arch ( J:179687 )

• hypoplastic at E9.5

absent second pharyngeal arch ( J:179687 )

• absent or hypoplastic at E9.5

small second pharyngeal arch ( J:179687 )

• absent or hypoplastic at E9.5

muscle

abnormal myocardial trabeculae morphology ( J:179687 )

• disorganized trabeculi within the ventricle