Phenotypes Associated with This Genotype

Genotype
MGI:5305443

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem; Jup^tm1Ruiz/Jup^tm1Ruiz; Olig2^tm1(cre)Tmj/Olig2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:178688 )

• mice survive until E10.5 and E13.5

nervous system

nervous system phenotype ( J:178688 )

N • mice exhibit normal lumbar motor column neuron specification, lateral migration, and segregation

abnormal neuronal migration ( J:178688 )

• some motor neurons fail to migrate away from the ventricular zone unlike in control mice

decreased motor neuron number ( J:178688 )

• in the spinal cord medial motor column

abnormal ventral interneuron 1 morphology ( J:178688 )

• mice exhibit a 2.5-fold increase in En1+ V1 interneurons and 3-fold increase in Chx10+ V2a interneurons compared to in control mice

abnormal ventral interneuron 2 morphology ( J:178688 )

• mice exhibit a 3-fold increase in Chx10+ V2a interneurons compared to in control mice

abnormal spinal cord motor column morphology ( J:178688 )

• at E11.5, mice exhibit intermixing of medial and lateral lumbar motor column neurons unlike in control mice

• at E13.5, preganglionic column neurons are scattered in ectopic ventral position unlike in control mice

• mice exhibit disorganization of intrasegmental neuron pools compared with control mice

• however, organization of rostro-caudal neurons are normal

abnormal spinal cord lateral motor column morphology ( J:178688 )

• Foxp1+ neurons are less densely packed than in control mice

• however, overall neuron packing is normal

abnormal spinal cord medial motor column morphology ( J:178688 )

• reduced number of neurons

cellular

abnormal neuronal migration ( J:178688 )

• some motor neurons fail to migrate away from the ventricular zone unlike in control mice