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Phenotypes Associated with This Genotype
Genotype
MGI:5305254
Allelic
Composition
Sirt1tm1.2Cxd/Sirt1tm1.2Cxd
Tg(Alb1-cre)1Dlr/?
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm1.2Cxd mutation (0 available); any Sirt1 mutation (66 available)
Tg(Alb1-cre)1Dlr mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• become significantly elevated
• liver is histologically normal at 2 months but with some lipid droplet accumulation
• livers at 6 months were fat in about 56% of mice
• livers at 12 months were fat in about 78% of mice but only 17% of controls

homeostasis/metabolism
• serum levels become modestly elevated
• becomes moderately elevated
• become significantly elevated

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
fatty liver disease DOID:9452 OMIM:228100
J:179193


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory