Phenotypes Associated with This Genotype

Genotype
MGI:5305076

• Allelic Composition: Rr7^tm3.1Kio/Rr7⁺; Tg(Lck-cre)#Nik/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )

• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8

• however, the number of CD4+(CD8+) decreases with age compared with Rr7^tm3.1Kio heterozygotes due to cre-mediated removal of the CD2 LCR

immune system

abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )

• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8

• however, the number of CD4+(CD8+) decreases with age compared with Rr7^tm3.1Kio heterozygotes due to cre-mediated removal of the CD2 LCR