Phenotypes Associated with This Genotype

Genotype
MGI:5305027

• Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu; Tg(Pax6-cre,GFP)2Pgr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:179393 )

• dopaminergic amacrine cells and neurites are clumped

• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive

• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons

abnormal retina ganglion cell morphology ( J:179393 )

• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina

nervous system

abnormal axon fasciculation ( J:179393 )

• of retinal dopaminergic and bNOS positive amacrine cell neurites

abnormal amacrine cell morphology ( J:179393 )

• dopaminergic amacrine cells and neurites are clumped

• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive

• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons

abnormal retina ganglion cell morphology ( J:179393 )

• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina

cellular

abnormal axon fasciculation ( J:179393 )

• of retinal dopaminergic and bNOS positive amacrine cell neurites