Phenotypes Associated with This Genotype

Genotype
MGI:5304715

• Allelic Composition: Egln1^tm1Kael/Egln1^tm1Kael; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

liver vascular congestion ( J:179490 )

• following thoracic aorta constriction, liver wet weight to dry weight is increased compared to in wild-type mice

pulmonary vascular congestion ( J:179490 )

• following thoracic aorta constriction, lung wet weight to dry weight is increased compared to in wild-type mice

increased angiogenesis ( J:179490 )

increased myocardial fiber size ( J:179490 )

• in aged mice

myocardial fiber degeneration ( J:179490 )

• following thoracic aorta constriction, mice exhibit myocyte dropout with replacement and interstitial fibrosis

enlarged heart ( J:179490 )

• following thoracic aorta constriction

increased heart weight ( J:179490 )

• following thoracic aorta constriction

abnormal heart left ventricle morphology ( J:179490 )

• following thoracic aorta constriction, mice exhibit increased left ventricular end-diastolic dimension compared with control mice

• aged mice exhibit left ventricular posterior wall thickness compared with control mice

cardiac interstitial fibrosis ( J:179490 )

• following thoracic aorta constriction

decreased heart ventricle muscle contractility ( J:179490 )

• following thoracic aorta constriction or left anterior descending artery and in aged mice

increased response of heart to induced stress ( J:179490 )

• following thoracic aorta constriction, mice exhibit increased cardiac hypertrophy, reduced cardiac function (decreased fractional shortening and increased left ventricular end-diastolic dimension and left ventricular posterior wall thickness), increased heart weight, cardiac interstitial fibrosis, enlarge myocardial fiber, and congestion in the lung and liver compared with wild-type mice

muscle

increased myocardial fiber size ( J:179490 )

• in aged mice

myocardial fiber degeneration ( J:179490 )

• following thoracic aorta constriction, mice exhibit myocyte dropout with replacement and interstitial fibrosis

decreased heart ventricle muscle contractility ( J:179490 )

• following thoracic aorta constriction or left anterior descending artery and in aged mice

homeostasis/metabolism

increased response of heart to induced stress ( J:179490 )

• following thoracic aorta constriction, mice exhibit increased cardiac hypertrophy, reduced cardiac function (decreased fractional shortening and increased left ventricular end-diastolic dimension and left ventricular posterior wall thickness), increased heart weight, cardiac interstitial fibrosis, enlarge myocardial fiber, and congestion in the lung and liver compared with wild-type mice

liver/biliary system

liver vascular congestion ( J:179490 )

• following thoracic aorta constriction, liver wet weight to dry weight is increased compared to in wild-type mice

respiratory system

pulmonary vascular congestion ( J:179490 )

• following thoracic aorta constriction, lung wet weight to dry weight is increased compared to in wild-type mice

cellular

cardiac interstitial fibrosis ( J:179490 )

• following thoracic aorta constriction

decreased mitochondrial number ( J:179490 )

• myocytes exhibit mitochondrial loss

growth/size/body

enlarged heart ( J:179490 )

• following thoracic aorta constriction

increased heart weight ( J:179490 )

• following thoracic aorta constriction