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Phenotypes Associated with This Genotype
Genotype
MGI:5304714
Allelic
Composition
Vhltm1Jae/Vhltm1Jae
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Vhltm1Jae mutation (2 available); any Vhl mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between P16 and P18 due to sudden cardiac death
• mean survival is 9 weeks

cardiovascular system
• at 5 weeks and severe at 8 weeks
• at 8 weeks, mice exhibit reduced left ventricular wall thickness and increased left ventricular end-diastolic dimension compared with control mice
• at 5 weeks and severe at 8 weeks
• neonates exhibit decreased heart rate at 10 days after birth
• neonates exhibit frequent cardiac arrhythmia, consistent with sudden cardiac death
• neonates exhibit increased QRS at 10 days after birth
• exhibit increased QTc (c denotes correction for heart rate) and QTc dispersion at 10 days after birth
• severe at 8 weeks of age

muscle
• at 5 weeks and severe at 8 weeks
• severe at 8 weeks of age

cellular
• myocytes exhibit mitochondrial loss

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
sudden infant death syndrome DOID:9007 OMIM:272120
J:193425


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/19/2018
MGI 6.12
The Jackson Laboratory