Phenotypes Associated with This Genotype

Genotype
MGI:5304493

• Allelic Composition: Tg(RP11-209M4)AGglo/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone mineral density ( J:179873 )

• with increasing age

decreased compact bone thickness ( J:179873 )

• in aging mice

abnormal bone ossification ( J:179873 )

• PTH-induced bone gain and bone formation rate are blunted compared to in similarly treated wild-type mice

• however, bone resorption in PTH-treated mice is normal

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:179873 )

• PTH-induced bone gain and bone formation rate are blunted compared to in similarly treated wild-type mice

• however, bone resorption in PTH-treated mice is normal