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Phenotypes Associated with This Genotype
Genotype
MGI:5302861
Allelic
Composition		 Pomt2tm1.1Hhu/Pomt2tm1.1Hhu
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomt2tm1.1Hhu mutation (1 available); any Pomt2 mutation (36 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule cell migration ( J:179356 )
• some granule cells fail to migrate in the cerebellum
• however, forebrain architecture is normal
abnormal cerebellum morphology ( J:179356 )
• adult mice exhibit breaches in the pial basement membrane and the glia limitans in limited areas at the midline between the cerebral hemispheres compared to in wild-type mice

cellular
abnormal cerebellar granule cell migration ( J:179356 )
• some granule cells fail to migrate in the cerebellum
• however, forebrain architecture is normal
abnormal basement membrane morphology ( J:179356 )
• adult mice exhibit breaches in the pial basement membrane and the glia limitans in limited areas at the midline between the cerebral hemispheres compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory