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Phenotypes Associated with This Genotype
Genotype
MGI:5302403
Allelic
Composition		 Coro1atm1Achn/Coro1atm1Achn
Coro1btm1.1Nfoe/Coro1btm1.1Nfoe
Genetic
Background		 involves: 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coro1atm1Achn mutation (0 available); any Coro1a mutation (23 available)
Coro1btm1.1Nfoe mutation (0 available); any Coro1b mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased mast cell degranulation ( J:177785 )
• more severe than in Coro1atm1Achn homozygotes
increased susceptibility to type I hypersensitivity reaction ( J:177785 )
• increased passive cutaneous anaphylaxis
decreased interleukin-6 secretion ( J:177785 )
• from bone marrow-derived mast cells stimulated with DNP-HSA as in Coro1atm1Achn homozygotes
• however, cellular production is normal
decreased tumor necrosis factor secretion ( J:177785 )
• from bone marrow-derived mast cells stimulated with DNP-HSA as in Coro1atm1Achn homozygotes
• however, cellular production is normal

hematopoietic system
increased mast cell degranulation ( J:177785 )
• more severe than in Coro1atm1Achn homozygotes

cellular
increased mast cell degranulation ( J:177785 )
• more severe than in Coro1atm1Achn homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory