Phenotypes Associated with This Genotype

Genotype
MGI:5302106

• Allelic Composition: Mir21a^tm1.1Mer/Mir21a^tm1.1Mer
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine level ( J:179235 )

abnormal interferon level ( J:179235 )

• increased IFNgamma in bronchoalveolar lavage fluid after allergic challenge

abnormal interleukin level ( J:179235 )

• increased IL12a in bronchoalveolar lavage fluid after allergic challenge

• decreased IL4 in bronchoalveolar lavage fluid after allergic challenge

increased susceptibility to type I hypersensitivity reaction ( J:179235 )

• increased IFNgamma, CXCL9, IL12a in bronchoalveolar lavage fluid after allergic challenge

• reduced IL4 and CCL17 in bronchoalveolar lavage fluid after allergic challenge

• significantly reduced eosinophil levels in bronchoalveolar lavage fluid and lung tissue after allergic challenge (OVA)

abnormal cytokine secretion ( J:179235 )

increased interferon-gamma secretion ( J:179235 )

• by stimulated CD4+ cells

increased interleukin-12 secretion ( J:179235 )

• increased secretion of IL12 by dendritic cells after LPS or LPS and IFNgamma stimulation

decreased interleukin-4 secretion ( J:179235 )

• by stimulated CD4+ cells

homeostasis/metabolism

abnormal cytokine level ( J:179235 )

abnormal interferon level ( J:179235 )

• increased IFNgamma in bronchoalveolar lavage fluid after allergic challenge

abnormal interleukin level ( J:179235 )

• increased IL12a in bronchoalveolar lavage fluid after allergic challenge

• decreased IL4 in bronchoalveolar lavage fluid after allergic challenge