Phenotypes Associated with This Genotype

Genotype
MGI:5301712

• Allelic Composition: Sting1^tm1Camb/Sting1^tm1Camb
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:179270 )

N • bacterial burden in the spleen is similar to controls after infection with either Listeria monocytogenes or Francisella tularensis

decreased circulating interferon-beta level ( J:179270 )

• IFNbeta production is significantly reduced at 8 hours but not at 24 hours after infection with either Listeria monocytogenes or Francisella tularensis

decreased circulating interleukin-6 level ( J:179270 )

• IL6 production is significantly reduced at 8 hours but not at 24 hours after infection with either Listeria monocytogenes or Francisella tularensis

homeostasis/metabolism

decreased circulating interferon-beta level ( J:179270 )

• IFNbeta production is significantly reduced at 8 hours but not at 24 hours after infection with either Listeria monocytogenes or Francisella tularensis

decreased circulating interleukin-6 level ( J:179270 )

• IL6 production is significantly reduced at 8 hours but not at 24 hours after infection with either Listeria monocytogenes or Francisella tularensis