About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5301577
Allelic
Composition
Cdkal1tm1.1Tomik/Cdkal1tm1.1Tomik
Tg(Ins2-cre)25Mgn/0
Genetic
Background
B6.Cg-Cdkal1tm1.1Tomik Tg(Ins2-cre)25Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkal1tm1.1Tomik mutation (0 available); any Cdkal1 mutation (38 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Endoplasmic reticulum distention in Cdkal1tm1.2Tomik/Cdkal1tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells

endocrine/exocrine glands
• the number of small islets is lower and the number of large islets is greater than in control mice
• however, the total number of islets is normal
• beta cells exhibit endoplasmic reticulum stress unlike control cells
• beta cells exhibit decreased glucose-stimulated ATP synthesis compared with control cells
• the first-phase of insulin secretion is impaired
• however, the second-phase is normal
• in beta cells 15 minutes after glucose challenge
• following prostprandial stimulation
• in mice fed a high-fat diet

homeostasis/metabolism
• the first-phase of insulin secretion is impaired
• however, the second-phase is normal
• in beta cells 15 minutes after glucose challenge
• following prostprandial stimulation
• in mice fed a high-fat diet
• in fasting and nonfasting mice fed a high-fat diet
• at 5 to 10 weeks of age
• in mice fed a high-fat diet

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:178248


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory