Mouse Genome Informatics
cn
    Cdkal1tm1.1Tomik/Cdkal1tm1.1Tomik
Tg(Ins2-cre)25Mgn/0

B6.Cg-Cdkal1tm1.1Tomik Tg(Ins2-cre)25Mgn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Endoplasmic reticulum distention in Cdkal1tm1.2Tomik/Cdkal1tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells

endocrine/exocrine glands
• the number of small islets is lower and the number of large islets is greater than in control mice
• however, the total number of islets is normal
• beta cells exhibit endoplasmic reticulum stress unlike control cells
• beta cells exhibit decreased glucose-stimulated ATP synthesis compared with control cells
• the first-phase of insulin secretion is impaired
• however, the second-phase is normal
• in beta cells 15 minutes after glucose challenge
• following prostprandial stimulation
• in mice fed a high-fat diet

homeostasis/metabolism
• the first-phase of insulin secretion is impaired
• however, the second-phase is normal
• in beta cells 15 minutes after glucose challenge
• following prostprandial stimulation
• in mice fed a high-fat diet
• in fasting and nonfasting mice fed a high-fat diet
• at 5 to 10 weeks of age
• in mice fed a high-fat diet

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:178248