About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5301410
Allelic
Composition
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0
Genetic
Background
FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc1tm1Bor mutation (0 available); any Abcc1 mutation (35 available)
Tg(Thy1-AppDutch)#Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

homeostasis/metabolism
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:178230


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory