Mouse Genome Informatics
cx
    Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0

FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy

homeostasis/metabolism
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:178230