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Phenotypes Associated with This Genotype
Genotype
MGI:5301408
Allelic
Composition		 Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background		 FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (82 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:178230 )
• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
amyloid beta deposits ( J:178230 )
• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory