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Phenotypes Associated with This Genotype
Genotype
MGI:5300899
Allelic
Composition		 Ighatm1Grh/Ighatm1Grh
Tg(Tnfsf13b)1Fma/Tg(Tnfsf13b)1Fma
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm1Grh mutation (2 available); any Igha mutation (18 available)
Tg(Tnfsf13b)1Fma mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:178227 )
N
• double mutant do not exhibit the impaired kidney function seen in single Tg(Tnfsf13b)1Fma homozygotes and have reduced levels of serum IgA and IgA deposits in the kidney, and reduced hematuria, urinary protein and albumin levels indicating that IgA is important for renal disease development in Tg(Tnfsf13b)1Fma homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory