Phenotypes Associated with This Genotype

Genotype
MGI:5300538

• Allelic Composition: Zbtb1^m1Btlr/Zbtb1^m1Btlr
• Genetic Background: involves: C3H/HeN * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:178820 )

N • the number of myeloid cells in the spleen is normal

abnormal thymus morphology ( J:178820 )

• thymi lack cortico-medullary definition

thymus hypoplasia ( J:178820 )

• severe

decreased DN2 thymocyte number ( J:178820 )

decreased DN3 thymocyte number ( J:178820 )

decreased DN4 thymocyte number ( J:178820 )

abnormal B cell differentiation ( J:178820 )

• mice exhibit an accumulation of B cell progenitors at the Hardy Fraction C stage, with a subsequent reduction of progenitors at the later stages

decreased transitional stage B cell number ( J:178820 )

• in the spleen

abnormal T cell differentiation ( J:178820 )

• thymocyte development is impaired from the early thymic precursor stage and beyond

• bone marrow cells exhibit competitive failure of lymphoid reconstitution in Rag1 null mice

decreased double-positive T cell number ( J:178820 )

decreased B cell number ( J:178820 )

• in the spleen

decreased follicular B cell number ( J:178820 )

• in the spleen

increased B cell number ( J:178820 )

• 20-fold in the thymus

decreased NK cell number ( J:178820 )

• in the spleen

decreased T cell number ( J:178820 )

• in the spleen

• T cells fail to develop with the exception of T cells that arise from a somatic revertant mutation (cysteine to serine at position 74)

decreased CD4-positive, alpha-beta T cell number ( J:178820 )

decreased CD8-positive, alpha-beta T cell number ( J:178820 )

abnormal immune system physiology ( J:178820 )

• mice lack T-independent immune response

• however, T-dependent immune response is normal

hematopoietic system

hematopoietic system phenotype ( J:178820 )

N • the number of myeloid cells in the spleen is normal

abnormal thymus morphology ( J:178820 )

• thymi lack cortico-medullary definition

thymus hypoplasia ( J:178820 )

• severe

decreased DN2 thymocyte number ( J:178820 )

decreased DN3 thymocyte number ( J:178820 )

decreased DN4 thymocyte number ( J:178820 )

abnormal B cell differentiation ( J:178820 )

• mice exhibit an accumulation of B cell progenitors at the Hardy Fraction C stage, with a subsequent reduction of progenitors at the later stages

decreased transitional stage B cell number ( J:178820 )

• in the spleen

abnormal T cell differentiation ( J:178820 )

• thymocyte development is impaired from the early thymic precursor stage and beyond

• bone marrow cells exhibit competitive failure of lymphoid reconstitution in Rag1 null mice

decreased B cell number ( J:178820 )

• in the spleen

decreased follicular B cell number ( J:178820 )

• in the spleen

increased B cell number ( J:178820 )

• 20-fold in the thymus

decreased NK cell number ( J:178820 )

• in the spleen

decreased T cell number ( J:178820 )

• in the spleen

• T cells fail to develop with the exception of T cells that arise from a somatic revertant mutation (cysteine to serine at position 74)

decreased double-positive T cell number ( J:178820 )

decreased CD4-positive, alpha-beta T cell number ( J:178820 )

decreased CD8-positive, alpha-beta T cell number ( J:178820 )

endocrine/exocrine glands

abnormal thymus morphology ( J:178820 )

• thymi lack cortico-medullary definition

thymus hypoplasia ( J:178820 )

• severe

decreased DN2 thymocyte number ( J:178820 )

decreased DN3 thymocyte number ( J:178820 )

decreased DN4 thymocyte number ( J:178820 )