Phenotypes Associated with This Genotype

Genotype
MGI:5300185

• Allelic Composition: Tg(PDGFB-LRRK2*R1441C)574Djmo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased vertical activity ( J:171645 )

• reduction in vertical locomotor activity by 15 months of age

decreased locomotor activity ( J:171645 )

• reduction in horizonal locomotor activity by 15 months of age

nervous system

abnormal neuron morphology ( J:171645 )

• neuronal soma from the cerebral cortex and striatum of 20-23 month old mice exhibit condensed aggregated mitochondria, damaged mitochondria and an increase in the density of autophagic vacuoles

homeostasis/metabolism

abnormal autophagy ( J:171645 )

• observed in the brains of aged mice

decreased circulating noradrenaline level ( J:171645 )

• decrease in cortical norepinephrine levels

decreased dopamine level ( J:171645 )

• decrease in cortical dopamine levels

cellular

abnormal autophagy ( J:171645 )

• observed in the brains of aged mice