Phenotypes Associated with This Genotype

Genotype
MGI:5299347

• Allelic Composition: Traf3ip1^{Gt(RRJ005)Byg}/Traf3ip1^{Gt(RRJ005)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:178483 )

embryo

absent embryonic cilia ( J:178483 )

• embryonic fibroblasts fail to form cilia in vitro

abnormal neural tube morphology ( J:178483 )

• neural tube patterning abnormalities consistent with defects in cilia

limbs/digits/tail

polydactyly ( J:178483 )

• at E13.5

curly tail ( J:178483 )

• at E10.5

homeostasis/metabolism

cardiac edema ( J:178483 )

• cardiac edema at E13.5

nervous system

abnormal nervous system development ( J:178483 )

• at E10.5

abnormal neural tube morphology ( J:178483 )

• neural tube patterning abnormalities consistent with defects in cilia

vision/eye

microphthalmia ( J:178483 )

• in several mice at E10.5

cellular

absent embryonic cilia ( J:178483 )

• embryonic fibroblasts fail to form cilia in vitro