Phenotypes Associated with This Genotype

Genotype
MGI:5299143

• Allelic Composition: Tg(Camk2a-Setdb1)1Akba/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:178512 )

N • mice exhibit normal survival

behavior/neurological

behavior/neurological phenotype ( J:160826 , J:178512 )

N • mice exhibit normal shock-associated reactivity and memory, novelty-induced locomotion activity, and anxiety-related behaviors (J:160826)

N • mice exhibit normal neurological function (J:178512)

abnormal depression-related behavior ( J:160826 )

• mice exhibit increased antidepressive behavior (increased sucrose consumption in an anhedonia test and decreased despair in a forced swim test) compared with wild-type mice

impaired coordination ( J:160826 )

• subtle decrease

nervous system

abnormal excitatory postsynaptic potential ( J:160826 )

• medium spiny neuron excitatory postsynaptic potential is not sensitive to NR2B/Grin2b antagonist unlike wild-type neurons

abnormal NMDA-mediated synaptic currents ( J:160826 )

• mice exhibit accelerated NMDA current desensitization compared with wild-type mice