Phenotypes Associated with This Genotype

Genotype
MGI:5298850

• Allelic Composition: Tg(YAC18)18Hay/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:144917 )

• mice are protected from apoptotic neurodegeneration induced by NMDA, straurosporine, or caffeine

• however, glutamate induced neuronal excitotoxicity is normal

cellular

decreased susceptibility to neuronal excitotoxicity ( J:144917 )

• mice are protected from apoptotic neurodegeneration induced by NMDA, straurosporine, or caffeine

• however, glutamate induced neuronal excitotoxicity is normal

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:144917 )

• mice are protected from apoptotic neurodegeneration induced by NMDA, straurosporine, or caffeine

• however, glutamate induced neuronal excitotoxicity is normal