Phenotypes for Arx Nkx2-2 Tg(Ins2-cre)23Herr MGI:5297819 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Arx^tm1Gldn/Arx^tm1Gldn Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0
Genetic Background	involves: 129 * Black Swiss * C57BL/6 * CBA/J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arx^tm1Gldn mutation (0 available); any Arx mutation (20 available)
Nkx2-2^tm2.1Suss mutation (0 available); any Nkx2-2 mutation (14 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:177838 )

N	• beta cell do not transdifferentiate into alpha cells unlike in Nkx2-2^tm2.1Suss homozygotes

decreased pancreatic beta cell number ( J:177838 )

• at E18.5

homeostasis/metabolism

hyperglycemia ( J:177838 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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