Phenotypes for Kitl Tg(Mt1-RET)304Ina MGI:5297720 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Kitl^Sl-d/Kitl^Sl-d Tg(Mt1-RET)304Ina/0
Genetic Background	involves: BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitl^Sl-d mutation (3 available); any Kitl mutation (92 available)
Tg(Mt1-RET)304Ina mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased melanoma incidence ( J:88074 )

• while fewer mutants develop malanocytic tumors than single Tg(Mt1-RET)304Ina/0 mice, mutants develop more malanocytic tumors than in wild-type controls

decreased tumor incidence ( J:88074 )

• mutants exhibit suppression of melanoma development compared to single Tg(Mt1-RET)304Ina/0 mice, with fewer mutants developing melanocytic tumors and prolonged survival

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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