Phenotypes Associated with This Genotype

Genotype
MGI:5297714

• Allelic Composition: Tg(Mt1-RET)304Ina/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:88074 )

• 70% of mutants die within 12 months after birth of rapidly growing melanoma

• average lifespan of mutants with melanoma is 9.7 +/- 3 months

neoplasm

increased metastatic potential ( J:155735 )

• 43.8% of mutants with malignant tumors (melanoma) exhibit lung metastasis

increased melanoma incidence ( J:155735 )

• mutants develop melanoma via multistep melanomagenesis, beginning with being tumor-free, then benign tumors, premalignant, and malignant stage tumors

• mutants develop solitary or multiple primary dome-shaped tumors on the eyes and skin of the head, neck, trunk, limbs, and tail

• 82.6% of tumors with sizes of less than 500 mm³ are benign and 17.4% are premalignant

• all tumors with sizes of 4,000 mm³ are malignant

• more than 80% of tumors with sizes of 500-4,000 mm³ are premalignant

increased cutaneous melanoma incidence ( J:88074 , J:155735 )

• mutants spontaneously develop melanoma (J:88074)

• mutants show tumors by 3.7 months of age (J:88074)

integument

increased cutaneous melanoma incidence ( J:88074 , J:155735 )

• mutants spontaneously develop melanoma (J:88074)

• mutants show tumors by 3.7 months of age (J:88074)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:155735