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Phenotypes Associated with This Genotype
Genotype
MGI:5297597
Allelic
Composition		 Ccm2tm1Etl/Ccm2tm1Etl
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2tm1Etl mutation (0 available); any Ccm2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular endothelial cell morphology ( J:177584 )
• endothelial cells transduced with TAT-Cre recombinase to mediate Ccm2 gene ablation exhibit altered composition and organization of tight junctions and adherens junctions
• endothelial monolayer permeability is increased in cells transduced with TAT-Cre recombinase to mediate Ccm2 gene ablation in the cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory