Phenotypes Associated with This Genotype

Genotype
MGI:5297581

• Allelic Composition: Foxe3^rct/Foxe3^rct
• Genetic Background: SJL/J-Foxe3^rct

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Slit-lamp photographs of eyes of 4 month old SJL/J and rct/rct mice.

vision/eye

abnormal lens morphology ( J:177496 )

• at P0, lens nuclei localization is altered compared to in wild-type mice

• at P5, lenses contain many nuclei in the posterior compartments compared with wild-type mice

abnormal lens development ( J:177496 )

• at E14.5, the anterior region of the lens is disorganized where the lens epithelia is reduced compared to in wild-type mice

abnormal lens epithelium morphology ( J:177496 )

• at E14.5 and E15.5, lens epithelium is reduced compared to in wild-type mice

• at P0, the anterior lens epithelium is thinner than in wild-type mice

• at P28, lens epithelia exhibits a loss of gap junction

abnormal lens fiber morphology ( J:177496 )

• at P28, lens fibers contain huge vacuoles and loss of gap junction unlike in wild-type mice

disorganized secondary lens fibers ( J:177496 )

• at P5 and progressively more disorganized with time

cortical cataract ( J:177496 )

• within 3 months of birth

anterior polar cataract ( J:177496 )

• within 3 months of birth