About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5297540
Allelic
Composition		 Aqp4tm1.1Geno/Aqp4tm1.1Geno
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp4tm1.1Geno mutation (0 available); any Aqp4 mutation (42 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood-brain barrier function ( J:177412 )
• after water injection, mice exhibit decreased water uptake compared with similarly treated wild-type mice
• basal brain water content is increased compared to in wild-type mice
• however, the blood-brain barrier is intake in a Evans dye transfer assay

nervous system
abnormal blood-brain barrier function ( J:177412 )
• after water injection, mice exhibit decreased water uptake compared with similarly treated wild-type mice
• basal brain water content is increased compared to in wild-type mice
• however, the blood-brain barrier is intake in a Evans dye transfer assay

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory