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Phenotypes Associated with This Genotype
Genotype
MGI:5297380
Allelic
Composition
Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob
Tg(Dmp1-cre)1Jqfe/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dmp1-cre)1Jqfe mutation (4 available)
Tnfsf11tm1.1Caob mutation (1 available); any Tnfsf11 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• mice exhibit normal tooth eruption and growth plates
• mice suspended by their tails for 3 weeks are protected from loss of bone and changes in cancellous architecture compared with similarly treated wild-type mice
• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice
• BMD increases progressively in the spine
• BMD increases progressively in the femur
• at 6 months of age in the femur and spine
• in mice suspended by their tails for 3 weeks
• mice suspended by their tails for 3 weeks exhibit increased trabecular spacing compared with similarly treated wild-type mice

immune system
• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice

hematopoietic system
• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory