Phenotypes Associated with This Genotype

Genotype
MGI:5297331

• Allelic Composition: Six1^tm1Mair/Six1^tm1Mair
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spectrum of abnormalities of great artery patterning in mice with null mutation of one or both copies of Six1^tm1Mair and Eya1^tm1Rilm

cardiovascular system

abnormal common carotid artery morphology ( J:172023 )

• 5% of embryos display duplicated left common carotid artery

abnormal cardiac outflow tract development ( J:172023 )

• 5% of mutants have great vessel defects

growth/size/body

abnormal face development ( J:172023 )

• dysmorphogenesis of the midface and deformation of nasal structures are observed in some embryos

abnormal midface morphology ( J:172023 )

• dysmorphogenesis of the midface

craniofacial

micrognathia ( J:172023 )

abnormal face development ( J:172023 )

• dysmorphogenesis of the midface and deformation of nasal structures are observed in some embryos

abnormal midface morphology ( J:172023 )

• dysmorphogenesis of the midface

muscle

abnormal skeletal muscle morphology ( J:172023 )

• embryos have severely hypoplastic branchiomeric muscles

skeleton

micrognathia ( J:172023 )