Phenotypes Associated with This Genotype

Genotype
MGI:5297329

• Allelic Composition: Eya1^tm1Rilm/Eya1^tm1Rilm; Six1^tm1Mair/Six1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spectrum of abnormalities of great artery patterning in mice with null mutation of one or both copies of Six1^tm1Mair and Eya1^tm1Rilm

cardiovascular system

retroesophageal right subclavian artery ( J:172023 )

• observed in 44% of embryos

interrupted aortic arch ( J:172023 )

• observed in 56% of embryos

vascular ring ( J:172023 )

• observed in 11% of embryos

abnormal cardiac outflow tract development ( J:172023 )

• 100% of compound mutants display outflow tract defects; most show multiple abnormalities

double outlet right ventricle ( J:172023 )

• observed in 33% of embryos