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Phenotypes Associated with This Genotype
Genotype
MGI:5297177
Allelic
Composition		 Gjb2tm1Ugds/Gjb2tm1Ugds
Tg(Sox10-cre)1Wdr/0
Genetic
Background		 involves: 129S2/SvPasCrl * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjb2tm1Ugds mutation (2 available); any Gjb2 mutation (20 available)
Tg(Sox10-cre)1Wdr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal hair cell physiology ( J:178055 )
• cochlear cultures fail to propagate calcium signals or release ATP following photostimulation with caged IP3 unlike wild-type cultures

nervous system
abnormal hair cell physiology ( J:178055 )
• cochlear cultures fail to propagate calcium signals or release ATP following photostimulation with caged IP3 unlike wild-type cultures

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory