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Phenotypes Associated with This Genotype
Genotype
MGI:5297173
Allelic
Composition		 Col10a1tm1(cre)Haak/Col10a1+
Tg(CAG-mRFP1,-SOX9,-EGFP)1Haak/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col10a1tm1(cre)Haak mutation (0 available); any Col10a1 mutation (28 available)
Tg(CAG-mRFP1,-SOX9,-EGFP)1Haak mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal bone mineralization ( J:176952 )
• mineralization eventually occurs, but mineralized domain is markedly reduced compared to controls
abnormal endochondral bone ossification ( J:176952 )
• endochondral bone formation is impaired
abnormal chondrocyte physiology ( J:176952 )
• terminal differentiation of hypertrophic chondrocytes is delayed as is subsequent cartilage replacement by bone

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory