Mouse Genome Informatics
cn
    Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Trp53tm1Brd/Trp53+

involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• mutants develop hyperplastic alveolar nodules (J:132088)

tumorigenesis
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive
• mutants develop mammary gland preneoplasia
• some preneoplasia are Esr1-negative while others are Esr1-positive

integument
• mutants develop hyperplastic alveolar nodules (J:132088)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast-Ovarian Cancer, Familial, Susceptibility to, 1; BROVCA1 604370 J:132088