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Phenotypes Associated with This Genotype
Genotype
MGI:5297135
Allelic
Composition
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (80 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Esr1)#Paf mutation (0 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mutants develop hyperplastic alveolar nodules
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive

neoplasm
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive
• mutants develop mammary gland preneoplasia
• some preneoplasia are Esr1-negative while others are Esr1-positive

integument
• mutants develop hyperplastic alveolar nodules
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary breast ovarian cancer DOID:5683 OMIM:604370
OMIM:612555
OMIM:613399
OMIM:614291
J:132088


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory