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Phenotypes Associated with This Genotype
Genotype
MGI:5297134
Allelic
Composition
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (73 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (147 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen
• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to mutants with wild-type Trp53 and also an increase in the percentage of mice with hyperplastic alveolar nodules
• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen
• cancers are Esr1-negative

tumorigenesis
• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen
• cancers are Esr1-negative
• mutants develop mammary gland preneoplasia that are Esr1-negative

renal/urinary system
• 25% of mutants develop ureteral obstruction 1-3 months after estrogen pellet placement

integument
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen
• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to mutants with wild-type Trp53 and also an increase in the percentage of mice with hyperplastic alveolar nodules
• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen
• cancers are Esr1-negative

cellular
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory