Phenotypes Associated with This Genotype

Genotype
MGI:5297086

• Allelic Composition: Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka; Tg(Dmp1-cre)1Jqfe/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:177557 )

N • mice exhibit normal tooth eruption

decreased osteoclast cell number ( J:177557 )

increased bone volume ( J:177557 )

• at 12 weeks of age

increased trabecular bone volume ( J:177557 )

• filling the bone marrow cavity at 12 weeks of age

increased bone mass ( J:177557 )

• with age beginning postnatally

osteopetrosis ( J:177557 )

• severe postnatally

abnormal cartilage morphology ( J:177557 )

• mice exhibit cartilage remnants unlike control mice

abnormal bone ossification ( J:177557 )

• bone formation is decreased compared to in control mice

decreased bone resorption ( J:177557 )

immune system

decreased osteoclast cell number ( J:177557 )

growth/size/body

growth/size/body region phenotype ( J:177557 )

N • mice exhibit normal growth

hematopoietic system

decreased osteoclast cell number ( J:177557 )