Phenotypes Associated with This Genotype

Genotype
MGI:5296949

• Allelic Composition: Tg(Alb-Nos2)1Mkan/?
• Genetic Background: FVB-Tg(Alb-Nos2)1Mkan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:177591 )

hyperglycemia ( J:177591 )

• after 4 hours of fasting as compared to controls when measured at 10 and 15 weeks of age

• blood glucose levels after overnight fasting are like controls

abnormal glycogen homeostasis ( J:177591 )

• impaired insulin induced suppression of hepatic glucose output after 14 hours of fasting

• glucose output reduced 71% compared to 32% for controls during hyperinsulinemic euglycemic clamp

decreased liver glycogen level ( J:177591 )

• significantly reduced relative to controls after a 4 hour fast

• liver glycogen levels are similar to control levels after an overnight fast

increased triglyceride level ( J:177591 )

increased circulating triglyceride level ( J:177591 )

increased circulating VLDL triglyceride level ( J:177591 )

• increased triglyceride rich VLDL

increased liver triglyceride level ( J:177591 )

behavior/neurological

behavior/neurological phenotype ( J:177591 )

N • food intake is normal

liver/biliary system

decreased liver glycogen level ( J:177591 )

• significantly reduced relative to controls after a 4 hour fast

• liver glycogen levels are similar to control levels after an overnight fast

increased liver triglyceride level ( J:177591 )