Phenotypes Associated with This Genotype

Genotype
MGI:5296861

• Allelic Composition: Itgb1^tm1Ref/Itgb1^tm12.1Ref; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hair and skin phenotypes of various keratinocyte conditional Itgb1 alleles

cellular

decreased keratinocyte adhesion ( J:177979 , J:203018 )

• keratinocytes exhibit impaired adhesion to a collagen/fibronectin coated plastic dishes compared with control cells (J:177979)

• keratinocytes do not adhere (J:203018)

integument

decreased keratinocyte adhesion ( J:177979 , J:203018 )

• keratinocytes exhibit impaired adhesion to a collagen/fibronectin coated plastic dishes compared with control cells (J:177979)

• keratinocytes do not adhere (J:203018)

abnormal hair growth ( J:177979 )

• at P14, abnormally shaped hair follicles fail to grow as deeply into the subcutis compared to in control mice

alopecia ( J:177979 )

• at 5 weeks, mice lose almost all their hair coat unlike controls

sparse hair ( J:203018 )

abnormal hair follicle morphology ( J:177979 )

• at 14 days of age

abnormal hair follicle development ( J:177979 )

• at 2 weeks, hair coat development is impaired compared with control mice

decreased hair follicle number ( J:177979 )

enlarged hair follicles ( J:203018 )

thick epidermis ( J:177979 )

• hyperthickened with aberrant shaped cells at 14 days of age

blistering ( J:177979 )

• at the epidermal-dermal junction at 14 days of age

reddish skin ( J:177979 )

skin lesions ( J:177979 )

• at 5 weeks due to mechanical stress

abnormal skin pigmentation ( J:177979 )

• at 2 weeks, skin pigmentation is impaired compared with control mice

pigmentation

abnormal skin pigmentation ( J:177979 )

• at 2 weeks, skin pigmentation is impaired compared with control mice