Phenotypes Associated with This Genotype

Genotype
MGI:5296817

• Allelic Composition: Atp1a2^tm4.1Ling/Atp1a2^tm4.1Ling; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: Black Swiss * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:177051 )

N • mice exhibit normal basal cardiac and vascular function

increased heart weight ( J:177051 )

• slight at 8 months of age

cardiac hypertrophy ( J:177051 )

• mild at 8 months of age

abnormal systemic arterial blood pressure ( J:177051 )

• mice fail to develop ACTH- or ouabain-induced hypertension unlike similarly treated wild-type mice

• however, basal systemic blood pressure is normal

growth/size/body

increased heart weight ( J:177051 )

• slight at 8 months of age

cardiac hypertrophy ( J:177051 )

• mild at 8 months of age