Phenotypes Associated with This Genotype

Genotype
MGI:5296796

• Allelic Composition: Gucy1b1^tm1Zhen/Gucy1b1^tm1Zhen; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal platelet physiology ( J:177066 )

• NO-induced cGMP production is abolished in platelets compared to in control cells

• agonist-induced cGMP production is reduced in platelets compared to in control cells

decreased platelet aggregation ( J:177066 )

• collagen- or thrombin-induced platelet secretion and aggregation are attenuated unlike in control cells

• however, high concentrations of agonists induce normal aggregation

decreased susceptibility to induced thrombosis ( J:177066 )

• time to form FeCl3-induced carotid artery thrombosis is prolonged compared to in control mice

increased bleeding time ( J:177066 )

cardiovascular system

cardiovascular system phenotype ( J:177066 )

N • mice exhibit normal blood pressure

hematopoietic system

hematopoietic system phenotype ( J:177066 )

N • mice exhibit normal blood counts, including platelets

abnormal platelet physiology ( J:177066 )

• NO-induced cGMP production is abolished in platelets compared to in control cells

• agonist-induced cGMP production is reduced in platelets compared to in control cells

decreased platelet aggregation ( J:177066 )

• collagen- or thrombin-induced platelet secretion and aggregation are attenuated unlike in control cells

• however, high concentrations of agonists induce normal aggregation