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Phenotypes Associated with This Genotype
Genotype
MGI:5296666
Allelic
Composition		 Rb1tm1Tyj/Rb1tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Tyj mutation (5 available); any Rb1 mutation (107 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
abnormal cell differentiation ( J:175625 )
• mouse embryonic fibroblasts transfected with a vector expressing Myod1 (MyoD) fail to differentiate into myocytes unlike similarly treated wild-type cells
• transfection with a vector expressing Myhc partially rescues myocyte differentiation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory