Phenotypes Associated with This Genotype

Genotype
MGI:5296664

• Allelic Composition: Kdm5a^tm1.1Kael/Kdm5a^tm1.1Kael; Rb1^tm1Tyj/Rb1⁺
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:175625 )

• median survival is 72 weeks

neoplasm

increased pituitary gland tumor incidence ( J:175625 )

• in 8 of 10 mice; 3 of 4 with intermediate lobe origins and 1 in 4 anterior lobe origins

increased thyroid tumor incidence ( J:175625 )

• in 8 of 10 mice

nervous system

increased pituitary gland tumor incidence ( J:175625 )

• in 8 of 10 mice; 3 of 4 with intermediate lobe origins and 1 in 4 anterior lobe origins

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:175625 )

• in 8 of 10 mice; 3 of 4 with intermediate lobe origins and 1 in 4 anterior lobe origins

increased thyroid tumor incidence ( J:175625 )

• in 8 of 10 mice