Phenotypes for Kdm5a Rb1 MGI:5296663 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Kdm5a^tm1.1Kael/Kdm5a⁺ Rb1^tm1Tyj/Rb1⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm5a^tm1.1Kael mutation (1 available); any Kdm5a mutation (74 available)
Rb1^tm1Tyj mutation (5 available); any Rb1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pituitary gland tumor incidence ( J:175625 )

• in 15 of 18 mice; 9 of 12 with intermediate lobe origins, 1 in 12 anterior lobe origins, and 2 of 12 intermediate and anterior lobe origins

increased thyroid tumor incidence ( J:175625 )

• in 16 of 18 mice

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:175625 )

• in 15 of 18 mice; 9 of 12 with intermediate lobe origins, 1 in 12 anterior lobe origins, and 2 of 12 intermediate and anterior lobe origins

increased thyroid tumor incidence ( J:175625 )

• in 16 of 18 mice

nervous system

increased pituitary gland tumor incidence ( J:175625 )

• in 15 of 18 mice; 9 of 12 with intermediate lobe origins, 1 in 12 anterior lobe origins, and 2 of 12 intermediate and anterior lobe origins

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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