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Phenotypes Associated with This Genotype
Genotype
MGI:5296003
Allelic
Composition
C4btm1Crr/C4btm1Crr
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C4btm1Crr mutation (1 available); any C4b mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• reduced neutrophil infiltration of glomerulus relative to controls when injected with 0.5 mg and with 1.0mg of anti-glomerular basement membrane antiserum

homeostasis/metabolism
• thrombus formation only moderately reduced

immune system
• reduced neutrophil infiltration of glomerulus relative to controls when injected with 0.5 mg and with 1.0mg of anti-glomerular basement membrane antiserum
• mice show some protection from intranasal infection with the mouse-adapted SARS-CoV MA15 , showing less weight loss than in wild-type controls but more weight loss than in C3tm1Crr homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory