About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5295993
Allelic
Composition
C3tm1Crr/C3tm1Crr
Zbtb20Tg(PDGFB-APPSwInd)20Lms/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (3 available); any C3 mutation (100 available)
Zbtb20Tg(PDGFB-APPSwInd)20Lms mutation (1 available); any Zbtb20 mutation (56 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaque levels are doubled in the hippocampus and mid frontal cortex relative to controls at 17 months of age but normal at 12 months
• plasma amyloid levels are increased 51% at 17 months
• neuron loss in the CA3 region at 17 days relative to controls

immune system

hematopoietic system

homeostasis/metabolism
• plaque levels are doubled in the hippocampus and mid frontal cortex relative to controls at 17 months of age but normal at 12 months
• plasma amyloid levels are increased 51% at 17 months

cellular


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory