Phenotypes for Fbxl5 Ireb2 MGI:5295293 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Fbxl5^tm1Kei/Fbxl5^tm1Kei Ireb2^tm1Roua/Ireb2^tm1Roua
Genetic Background	B6.129-Fbxl5^tm1Kei Ireb2^tm1Roua

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5^tm1Kei mutation (0 available); any Fbxl5 mutation (43 available)
Ireb2^tm1Roua mutation (1 available); any Ireb2 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:176655 )

N	• unlike mice homozygous for the Fbxl5 mutation alone, double homozygous mice are viable

homeostasis/metabolism

increased circulating iron level ( J:176655 )

decreased circulating unsaturated transferrin level ( J:176655 )

• elevated transferrin saturation

decreased liver iron level ( J:176655 )

• compared to mice homozygous for the Ireb2 mutation alone

hematopoietic system

decreased hematocrit ( J:176655 )

decreased hemoglobin content ( J:176655 )

decreased mean corpuscular hemoglobin ( J:176655 )

decreased mean corpuscular hemoglobin concentration ( J:176655 )

decreased mean corpuscular volume ( J:176655 )

microcytosis ( J:176655 )

liver/biliary system

decreased liver iron level ( J:176655 )

• compared to mice homozygous for the Ireb2 mutation alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24