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Phenotypes Associated with This Genotype
Genotype
MGI:5295268
Allelic
Composition
Cntnap2tm1Pele/Cntnap2tm1Pele
Genetic
Background
B6.129-Cntnap2tm1Pele
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntnap2tm1Pele mutation (1 available); any Cntnap2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no differences are seen in the light-dark exploration test between mutants and wild-type mice (J:177110)
• mutants treated with the drug Risperidone exhibit rescue of the hyperactivity, repetitive behavior/perseveration and nesting deficits (J:177110)
• no differences are seen in the light-dark exploration test between mutants and wild-type mice (J:177110)
• mutants treated with the drug Risperidone exhibit rescue of the hyperactivity, repetitive behavior/perseveration and nesting deficits (J:177110)
• mutants spend almost 3 times more time grooming than wild-type mice (J:177110)
• mutants spend almost 3 times more time grooming than wild-type mice (J:177110)
• mutants perform similarly to wild-type mice in the Morris water maze probe trials, however in a classic reversal task using the Morris water maze, mutants show impaired learning of the new location of the platform and perform poorly in the probe test (J:177110)
• mutants perform similarly to wild-type mice in the Morris water maze probe trials, however in a classic reversal task using the Morris water maze, mutants show impaired learning of the new location of the platform and perform poorly in the probe test (J:177110)
• mutants perform better than wild-type mice on the rotorod (J:177110)
• mutants perform better than wild-type mice on the rotorod (J:177110)
• mutants show greater locomotor activity than wild-type mice in the open field test (J:177110)
• mutants treated with the drug Risperidone exhibit rescue of the hyperactivity (J:177110)
• mutants show greater locomotor activity than wild-type mice in the open field test (J:177110)
• mutants treated with the drug Risperidone exhibit rescue of the hyperactivity (J:177110)
• in the spontaneous alternation T maze test, mutants show higher number of no alternations in a standard 10 trial test, indicating preservation (J:177110)
• mutants treated with the drug Risperidone exhibit rescue of the repetitive behavior/perseveration (J:177110)
• in the spontaneous alternation T maze test, mutants show higher number of no alternations in a standard 10 trial test, indicating preservation (J:177110)
• mutants treated with the drug Risperidone exhibit rescue of the repetitive behavior/perseveration (J:177110)
• mutants exhibit hyperreactivity to thermal sensory stimuli (J:177110)
• however, no differences seen in the acoustic startle response or prepulse inhibition (J:177110)
• mutants exhibit hyperreactivity to thermal sensory stimuli (J:177110)
• however, no differences seen in the acoustic startle response or prepulse inhibition (J:177110)
• mutants are impaired in nest-building behavior, scoring less than half of the wild-type criterion (J:177110)
• mutants treated with the drug Risperidone exhibit rescue of the nesting deficits (J:177110)
• mutants are impaired in nest-building behavior, scoring less than half of the wild-type criterion (J:177110)
• mutants treated with the drug Risperidone exhibit rescue of the nesting deficits (J:177110)
• in a juvenile play test, mutants at P21 spend less time interacting with each other and instead show increased repetitive behaviors such as grooming and digging (J:177110)
• in a three-chamber social interaction test in adults, mutants do not show a preference for the cup with a mouse as seen in wild-type mice (J:177110)
• in a juvenile play test, mutants at P21 spend less time interacting with each other and instead show increased repetitive behaviors such as grooming and digging (J:177110)
• in a three-chamber social interaction test in adults, mutants do not show a preference for the cup with a mouse as seen in wild-type mice (J:177110)
• mutants emit a lower number of ultrasonic calls than wild-type mice at all ages (J:177110)
• mutants emit a lower number of ultrasonic calls than wild-type mice at all ages (J:177110)
• mutants older than 6 months of age commonly exhibit spontaneous seizures (J:177110)
• mutants older than 6 months of age commonly exhibit spontaneous seizures (J:177110)
• seizures are induced by mild stressors during routine handling (J:177110)
• seizures are induced by mild stressors during routine handling (J:177110)

integument
• mutants exhibit hyperreactivity to thermal sensory stimuli (J:177110)
• however, no differences seen in the acoustic startle response or prepulse inhibition (J:177110)
• mutants exhibit hyperreactivity to thermal sensory stimuli (J:177110)
• however, no differences seen in the acoustic startle response or prepulse inhibition (J:177110)

nervous system
• mutants older than 6 months of age commonly exhibit spontaneous seizures (J:177110)
• mutants older than 6 months of age commonly exhibit spontaneous seizures (J:177110)
• seizures are induced by mild stressors during routine handling (J:177110)
• seizures are induced by mild stressors during routine handling (J:177110)
• mutants exhibit a reduction in parvalbumin+ interneurons in the hippocampus (J:177110)
• mutants exhibit a decrease in the number of GABAergic interneurons in all laminae and in the striatum (J:177110)
• mutants exhibit a reduction in parvalbumin+ interneurons in the hippocampus (J:177110)
• mutants exhibit a decrease in the number of GABAergic interneurons in all laminae and in the striatum (J:177110)
• ectopic neurons are seen in the corpus callosum of mutants at P14; ectopic neurons are seen through adulthood (J:177110)
• ectopic neurons are seen in the corpus callosum of mutants at P14; ectopic neurons are seen through adulthood (J:177110)
• reactive astrocytosis is seen throughout the hippocampus after onset of seizures, especially in the hilus (J:177110)
• however, neuronal loss is not seen in the hippocampus (J:177110)
• reactive astrocytosis is seen throughout the hippocampus after onset of seizures, especially in the hilus (J:177110)
• however, neuronal loss is not seen in the hippocampus (J:177110)
• at 8 months of age, freely moving mutants exhibit generalized interictal spike discharges during slow-wave sleep (J:177110)
• at 8 months of age, freely moving mutants exhibit generalized interictal spike discharges during slow-wave sleep (J:177110)
• mutants exhibit reduced cortical neuronal synchrony as indicated by two-photon calcium imaging of layer II/III neurons from somatosensory cortex showing that neuronal firing pattern is highly asynchronous compared to wild-type mice (J:177110)
• however, neither the average firing amplitude nor the average firing rate are changed, suggesting that the defect is due to a network dysfunction rather than abnormalities in neuronal activity or conduction per se (J:177110)
• mutants exhibit reduced cortical neuronal synchrony as indicated by two-photon calcium imaging of layer II/III neurons from somatosensory cortex showing that neuronal firing pattern is highly asynchronous compared to wild-type mice (J:177110)
• however, neither the average firing amplitude nor the average firing rate are changed, suggesting that the defect is due to a network dysfunction rather than abnormalities in neuronal activity or conduction per se (J:177110)
• ectopic neurons are seen in the corpus callosum of mutants at P14 (J:177110)
• mutants exhibit abnormal migration of cortical projection neurons as evidenced by the higher numbers of CUX1+ cells in deep cortical layers (J:177110)
• ectopic neurons are seen in the corpus callosum of mutants at P14 (J:177110)
• mutants exhibit abnormal migration of cortical projection neurons as evidenced by the higher numbers of CUX1+ cells in deep cortical layers (J:177110)

taste/olfaction
• mutants perform better than wild-type mice in the buried food test, indicating better olfaction (J:177110)
• mutants perform better than wild-type mice in the buried food test, indicating better olfaction (J:177110)

cellular
• ectopic neurons are seen in the corpus callosum of mutants at P14 (J:177110)
• mutants exhibit abnormal migration of cortical projection neurons as evidenced by the higher numbers of CUX1+ cells in deep cortical layers (J:177110)
• ectopic neurons are seen in the corpus callosum of mutants at P14 (J:177110)
• mutants exhibit abnormal migration of cortical projection neurons as evidenced by the higher numbers of CUX1+ cells in deep cortical layers (J:177110)


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory