Mouse Genome Informatics
involves: 129P2/OlaHsd * C57BL/6J
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• mutants bury fewer marbles than wild-type mice in both the novel and homecage
• mutants spend less time and make fewer entries into the open arms of the elevated plus-maze than wild-type mice when started facing a closed arm
• a separate cohort of mutants spent more time and made more entries into the plus-maze open arms than wild-type mice when started facing an open arm
• mutants groom more than wild-type mice in the homecage but not in the novel cage
• on a T-maze spontaneous alternation test, mutants alternate less than wild-type mice, indicating repetitive exploration of the same arm
• mutants make more foot-slips than wild-type mice on a balance beam test, but only on the narrowest beam
• on the accelerating rotarod, mutants have lower latencies to fall than wild-type mice on all trials
• mutants have lower inverted hang latency than wild-type mice on an inverted cage test
• in the open-field test, mutants travel less and avoid the center more than wild-type mice
• following MPEP treatment, mutants exhibit similar novel open-field locomotion as vehicle-treated wild-type mice
• in a choice-based social approach test, mutants exhibit greater investigation of the mouse than wild-type mice
• following treatment with the anxiolytic drug, 2-methyl-6-phenylethynylpyridine (MPEP), mutants show relatively more social and novel-social behavior than controls
• mutants exhibit longer latency to first vocalization and make fewer vocalizations overall than wild-type mice

• on a non-exploration-based assay for anxiety-related behavior and stress reactivity, mutants show greater stress-induced hyperthermia than wild-type mice
• mutants exhibit greater stress-induced serum corticosterone response to restraint stress than wild-type mice

nervous system
• mutants exhibit no obvious differences in cerebellar morphology (J:175436)
• mutants exhibit larger spine headwidth than wild-type mice in relatively long dendritic spines in basolateral amygdala neurons, but not in anterior cingulated cortex neurons

Mouse Models of Human Disease
Autism 209850 J:175436
Williams-Beuren Syndrome; WBS 194050 J:175436