Phenotypes Associated with This Genotype

Genotype
MGI:5295198

• Allelic Composition: Zeb1^Tw/Zeb1⁺
• Genetic Background: B6.Cg-Zeb1^Tw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Inner ear morphology, hearing thresholds, and otoconia of Zeb1^Tw/Zeb1⁺ and Zeb1^Tw/Zeb1^Tw mice

behavior/neurological

increased food intake ( J:177274 )

• starting at 7 weeks of age mice consume 15 - 20% more food

circling ( J:177274 )

growth/size/body

increased body weight ( J:177274 )

obese ( J:177274 )

• in adults

adipose tissue

increased percent body fat/body weight ( J:177274 )

homeostasis/metabolism

abnormal circulating hormone level ( J:177274 )

increased circulating insulin level ( J:177274 )

increased circulating leptin level ( J:177274 )

abnormal circulating lipid level ( J:177274 )

increased circulating corticosterone level ( J:177274 )

increased circulating free fatty acids level ( J:177274 )

increased circulating triglyceride level ( J:177274 )

impaired glucose tolerance ( J:177274 )

• slight glucose intolerance in females at 15 weeks of age

insulin resistance ( J:177274 )

• in females at 15 weeks of age

increased circulating adiponectin level ( J:177274 )

• elevated in the serum

hearing/vestibular/ear

abnormal cochlea morphology ( J:177274 )

• average length of the cochlear duct is 91% that of wild-type controls

abnormal semicircular canal morphology ( J:177274 )

• the contours of the canals are irregular due to small bulges and projections

abnormal lateral semicircular canal morphology ( J:177274 )

• the non-ampullated ends are irregular or constricted

enlarged otoliths ( J:177274 )

• utricles have giant otoconia visible by scanning electron microscopy

increased or absent threshold for auditory brainstem response ( J:177274 )

• increase in the binaural average ABR thresholds at 1 month of age

hematopoietic system

small thymus ( J:177274 )

• in adults

decreased leukocyte cell number ( J:177274 )

• in adults

decreased neutrophil cell number ( J:177274 )

• decrease in the number of polymorphonuclear neutrophils in adults

decreased lymphocyte cell number ( J:177274 )

• in adults

small spleen ( J:177274 )

• in adults

immune system

small thymus ( J:177274 )

• in adults

decreased leukocyte cell number ( J:177274 )

• in adults

decreased neutrophil cell number ( J:177274 )

• decrease in the number of polymorphonuclear neutrophils in adults

decreased lymphocyte cell number ( J:177274 )

• in adults

small spleen ( J:177274 )

• in adults

endocrine/exocrine glands

small thymus ( J:177274 )

• in adults