Phenotypes Associated with This Genotype

Genotype
MGI:5295149

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺; Ppp1r13l^tm1Xlu/Ppp1r13l^tm1Xlu
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:177360 )

• tamoxifen-treated mouse embryonic fibroblasts exhibit a dramatic reduction of S phase entry compared with control mice

abnormal keratinocyte differentiation ( J:177360 )

• tamoxifen-treated primary keratinocyte cultures exhibit increased expression of differentiation markers compared with control cells

decreased fibroblast proliferation ( J:177360 )

• tamoxifen-treated mouse embryonic fibroblasts exhibit decreased proliferation and a 2- to 6-fold increase in slow cycling cells in passage 4 and 5 compared with control mice

early cellular replicative senescence ( J:177360 )

• in tamoxifen-treated mouse embryonic fibroblasts

integument

abnormal keratinocyte differentiation ( J:177360 )

• tamoxifen-treated primary keratinocyte cultures exhibit increased expression of differentiation markers compared with control cells