Phenotypes Associated with This Genotype

Genotype
MGI:5294924

• Allelic Composition: Tslp^tm1Mak/Tslp^tm1Mak
• Genetic Background: B6.Cg-Tslp^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:175844 )

• no mice survive beyond 14 days post treatment with DSS to induce colitis

• however, mice treated with a neutrophil elastase inhibition recover from DSS-induced colitis

digestive/alimentary system

digestive/alimentary phenotype ( J:175844 )

N • mice exhibit normal intestinal barrier function and colonic microbiota

colitis ( J:175844 )

• DSS-treated mice fail to recover from induced colitis compared with similarly treated wild-type mice

• however, mice exhibit normal onset, severity, and sensitivity to DSS-induced colitis with normal cytokine profile, and mice treated with a neutrophil elastase inhibition recover from DSS-induced colitis

growth/size/body

weight loss ( J:175844 )

• DSS-treated mice exhibit perisstent weight loss unlike similarly treated wild-type mice

immune system

immune system phenotype ( J:175844 )

N • mice exhibit normal regulatory T cell numbers and activation of dendritic cells

colitis ( J:175844 )

• DSS-treated mice fail to recover from induced colitis compared with similarly treated wild-type mice

• however, mice exhibit normal onset, severity, and sensitivity to DSS-induced colitis with normal cytokine profile, and mice treated with a neutrophil elastase inhibition recover from DSS-induced colitis

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:175844 )

• no mice survive beyond 14 days post treatment with DSS to induce colitis

• however, mice treated with a neutrophil elastase inhibition recover from DSS-induced colitis